South Wales Police are appealing for witnesses following a three-vehicle collision which occurred on Port Road West, Rhoose, at approximately 9.15am on Monday (12th April).
The collision involved a red Vauxhall Astra, a black Audi A3 and a grey Ford Focus.
It is understood there was a head-on collision between a black Audi and a Ford Focus.
The occupants of both those vehicles sustained life changing injuries. They are being treated at the University Hospital of Wales.
The driver of a third vehicle, a Vauxhall Astra, escaped without injury.
The road was closed for several hours to allow for the investigate work to be carried out. Motorists are thanked for their patience and cooperation during this time.
Anyone who witnessed the collision, or the manner in which any of the vehicles were being driven in the moments prior to it, is asked to contact police, quoting occurrence 2100125924.
You can contact police via https://bit.ly/SWPProvideInfo, email PublicServiceCentre@south-wales.police.uk or by calling101.